Palynziq (pegvaliase-pqpz) is a prescription medication used to treat phenylketonuria (PKU), a rare genetic disorder that affects the body’s ability to break down an amino acid called phenylalanine. Palynziq is an enzyme therapy that reduces phenylalanine levels in the blood by converting it to another amino acid that can be safely eliminated from the body.
Uses:
Palynziq is used to treat phenylketonuria (PKU), a rare genetic disorder that affects the body’s ability to break down an amino acid called phenylalanine.
Storage Conditions:
Palynziq should be stored refrigerated between 36°F to 46°F (2°C to 8°C). It should be protected from light and not be frozen.
Mechanism of Action:
Palynziq (pegvaliase-pqpz) is an enzyme therapy that converts phenylalanine to another amino acid. PKU results from a genetic mutation that prevents the body from properly breaking down phenylalanine, which can lead to intellectual disability, seizures, and other health problems. Palynziq converts phenylalanine to phenylpyruvate, which can be safely eliminated from the body, thereby reducing phenylalanine in the blood.
HOW TO USE:
Palynziq is administered as a subcutaneous injection by a healthcare provider. The recommended starting dose is 2.5 mg once daily, gradually increasing to a maintenance dose of 20 mg per day. The injection site should be rotated daily, and injections should not be given in the same area every day.
Precautions:
• Patients should inform their healthcare provider if they have a history of anaphylaxis or allergies to any injectable medication.
• Patients with a history of depression or suicidal ideation should be monitored closely while taking Palynziq.
• Palynziq may cause a drop in blood pressure, and patients should inform their healthcare provider if they experience dizziness, lightheadedness, or fainting.
Drug Interactions:
• Palynziq may interact with medications that affect blood pressure or heart rate.
Contraindications:
• Palynziq should not be used in patients with a history of anaphylaxis to pegvaliase-pqpz or any of its components.
Overdose:
There is limited information on the overdose of Palynziq. However, patients who experience an overdose of Palynziq should seek immediate medical attention.
Adverse Reactions:
The most common adverse reactions experienced by patients taking Palynziq include injection site reactions, such as pain, redness, or swelling, and allergic reactions. Other potential side effects include headache, nausea, and joint pain. Patients should contact their healthcare provider if they experience any unusual symptoms while taking Palynziq.
In conclusion, Palynziq (pegvaliase-pqpz) is an enzyme therapy used to treat phenylketonuria (PKU). It works by converting phenylalanine to another amino acid that can be safely eliminated from the body, thereby reducing phenylalanine in the blood. Palynziq should be stored refrigerated between 36°F to 46°F (2°C to 8°C) and is administered as a subcutaneous injection by a healthcare provider. Patients should inform their healthcare provider of any history of anaphylaxis or allergies to any injectable medication. They should also be monitored closely while taking Palynziq if they have a history of depression or suicidal ideation. Adverse reactions may include injection site reactions, allergic reactions, headache, nausea, and joint pain. Palynziq should not be used by those with a history of anaphylaxis to pegvaliase-pqpz or any of its components, and patients should inform their healthcare provider if they experience dizziness, lightheadedness, or fainting. Palynziq may interact with medications that affect blood pressure or heart rate, and overdose information is limited.
– Samantha T.
The titration phase took some patience, but once I reached the maintenance dose, the benefits became clear. My blood Phe levels dropped dramatically, and I noticed a huge improvement in mood and focus. Palynziq has given me more control over my PKU than I ever thought possible. It’s not a quick fix, but it’s a powerful one.
– Thomas G.
Palynziq has transformed my life. Before, I was stuck on a medical diet with very little flexibility. Now I can enjoy meals with my family without measuring everything down to the gram. It took a few months to adjust, but my body responded well, and my Phe levels are stable. I wish this had been available years ago.
– Natalie R.
I’ve lived with PKU my entire life, strictly managing my diet and protein intake. After starting Palynziq, I can finally eat a more normal diet without constant anxiety. My phenylalanine levels have dropped significantly, and I feel more mentally clear and energetic. The injections took some getting used to, but the results are absolutely worth it.